USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P02675 USC-OGP 2-DE database:  P02675 P02675 General information about the entry View entry in simple text format Entry name FIBB_HUMAN Primary accession number P02675 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor;. Gene name Name=FGB Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_4-7 {PLATELET 4-7} Homo sapiens (Human)   map experimental info   PLATELET_4-7 MAP LOCATIONS: SPOT OGP-0345: pI=5.93; Mw=54833 SPOT OGP-0351: pI=6.07; Mw=54328 SPOT OGP-0353: pI=6.34; Mw=52096 SPOT OGP-0355: pI=6.70; Mw=51969 SPOT OGP-0364: pI=6.53; Mw=50963 SPOT OGP-0371: pI=5.65; Mw=49130 SPOT OGP-0373: pI=5.97; Mw=49010 SPOT OGP-0376: pI=5.94; Mw=48772 PLATELET_5-6 {PLATELET 5-6} Homo sapiens (Human)   map experimental info   PLATELET_5-6 MAP LOCATIONS: SPOT OGP-0659: pI=5.87; Mw=53791 SPOT OGP-0686: pI=5.91; Mw=47741 SPOT OGP-0687: pI=5.94; Mw=47622 SPOT OGP-0694: pI=5.67; Mw=44976 PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0894: pI=6.90; Mw=52789 SPOT OGP-0895: pI=6.88; Mw=52647 SPOT OGP-0897: pI=7.06; Mw=52505 SPOT OGP-0898: pI=7.21; Mw=52505 SPOT OGP-0899: pI=6.15; Mw=52364 SPOT OGP-0900: pI=5.87; Mw=52223 SPOT OGP-0901: pI=6.63; Mw=52223 SPOT OGP-0903: pI=7.80; Mw=52223 SPOT OGP-0905: pI=6.08; Mw=52082 SPOT OGP-0906: pI=6.32; Mw=51802 SPOT OGP-0908: pI=6.53; Mw=50560 SPOT OGP-0921: pI=5.91; Mw=47681 Cross-references UniProtKB/Swiss-Prot P02675; FIBB_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name FIBB_HUMAN Primary accession number P02675 Secondary accession number(s) A0JLR9 B2R7G3 Q32Q65 Q3KPF2 Sequence was last modified on  July 1, 1993 (version 2) Annotations were last modified on  March 15, 2017 (version 205) Name and origin of the protein Description RecName: Full=Fibrinogen beta chain; Contains: RecName: Full=Fibrinopeptide B; Contains: RecName: Full=Fibrinogen beta chain; Flags: Precursor; Gene name Name=FGB Encoded on Name=FGB Keywords 3D-structure; Adaptive immunity; Blood coagulation; Coiled coil; Complete proteome; Direct protein sequencing; Disease mutation; Disulfide bond; Glycoprotein; Hemostasis; Immunity; Innate immunity; Polymorphism; Pyrrolidone carboxylic acid; Reference proteome; Secreted; Signal. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL J00129; AAA52429.1; -; mRNA EMBL J00131; AAA98115.1; -; Genomic_DNA EMBL J00130; AAA98115.1; JOINED; Genomic_DNA EMBL J00132; AAA98116.1; -; Genomic_DNA EMBL J00133; -; NOT_ANNOTATED_CDS; mRNA EMBL M64983; AAA18024.2; -; Genomic_DNA EMBL AF388026; AAK62470.1; -; Genomic_DNA EMBL AK312972; BAG35810.1; -; mRNA EMBL CH471056; EAX04932.1; -; Genomic_DNA EMBL BC007030; AAH07030.1; ALT_SEQ; mRNA EMBL BC106760; AAI06761.1; -; mRNA EMBL BC107766; AAI07767.1; -; mRNA EMBL AH002694; AAA52445.1; -; Genomic_DNA EMBL X05018; CAA28674.1; -; Genomic_DNA CCDS CCDS3786.1; -; . PIR B43568; FGHUB; . RefSeq NP_001171670.1; NM_001184741.1; . RefSeq NP_005132.2; NM_005141.4; . UniGene Hs.300774; -; . PDB 1FZA; X-ray; 2.90 A; B/E=164-491 PDB 1FZB; X-ray; 2.90 A; B/E=164-491 PDB 1FZC; X-ray; 2.30 A; B/E=164-491 PDB 1FZE; X-ray; 3.00 A; B/E=164-491 PDB 1FZF; X-ray; 2.70 A; B/E=164-491 M/N/S/T=45-48 PDB; 1FZG; X-ray; 2.50 A B/E=164-491 PDB; 1LT9; X-ray; 2.80 A B/E=179-491 PDB; 1LTJ; X-ray; 2.80 A B/E=179-491 PDB; 1N86; X-ray; 3.20 A B/E=164-491 I/J=45-51; PDB; 1N8E; X-ray 4.50 A B/E=164-491; PDB; 1RE3; X-ray 2.45 A B/E=179-491; PDB; 1RE4; X-ray 2.70 A B/E=179-491; PDB; 1RF0; X-ray 2.81 A B/E=179-491; PDB; 1RF1; X-ray 2.53 A B/E=179-491; PDB; 2A45; X-ray 3.65 A H/K=45-135; PDB; 2FFD; X-ray 2.89 A B/E=179-491; PDB; 2H43; X-ray 2.70 A B/E=164-491; PDB; 2HLO; X-ray 2.60 A B/E=164-491; PDB; 2HOD; X-ray 2.90 A B/E/H/K=164-491; PDB; 2HPC; X-ray 2.90 A B/E/H/K=164-491; PDB; 2OYH; X-ray 2.40 A B/E=179-491; PDB; 2OYI; X-ray 2.70 A B/E=179-491; PDB; 2Q9I; X-ray 2.80 A B/E=164-491; PDB; 2XNX; X-ray 3.30 A B/E/H/K=164-491; PDB; 2XNY; X-ray 7.50 A B/E=164-491; PDB; 2Z4E; X-ray 2.70 A B/E=164-489; PDB; 3BVH; X-ray 2.60 A B/E=191-488; PDB; 3E1I; X-ray 2.30 A B/E=164-491; PDB; 3GHG; X-ray 2.90 A B/E/H/K=31-491; PDB; 3H32; X-ray 3.60 A B/E=31-488; PDB; 3HUS; X-ray 3.04 A B/E=179-491; PDBsum; 1FZA; - PDBsum 1FZB; -; . PDBsum 1FZC; -; . PDBsum 1FZE; -; . PDBsum 1FZF; -; . PDBsum 1FZG; -; . PDBsum 1LT9; -; . PDBsum 1LTJ; -; . PDBsum 1N86; -; . PDBsum 1N8E; -; . PDBsum 1RE3; -; . PDBsum 1RE4; -; . PDBsum 1RF0; -; . PDBsum 1RF1; -; . PDBsum 2A45; -; . PDBsum 2FFD; -; . PDBsum 2H43; -; . PDBsum 2HLO; -; . PDBsum 2HOD; -; . PDBsum 2HPC; -; . PDBsum 2OYH; -; . PDBsum 2OYI; -; . PDBsum 2Q9I; -; . PDBsum 2XNX; -; . PDBsum 2XNY; -; . PDBsum 2Z4E; -; . PDBsum 3BVH; -; . PDBsum 3E1I; -; . PDBsum 3GHG; -; . PDBsum 3H32; -; . PDBsum 3HUS; -; . ProteinModelPortal P02675; -; . SMR P02675; -; . BioGrid 108535; 111; . DIP DIP-385N; -; . IntAct P02675; 16; . STRING 9606.ENSP00000306099; -; . ChEMBL CHEMBL2048; -; . DrugBank DB04919; Alfimeprase; . DrugBank DB00364; Sucralfate; . iPTMnet P02675; -; . PhosphoSitePlus P02675; -; . SwissPalm P02675; -; . UniCarbKB P02675; -; . BioMuta FGB; -; . DMDM 399492; -; . DOSAC-COBS-2DPAGE P02675; -; . OGP P02675; -; . REPRODUCTION-2DPAGE IPI00298497; -; . REPRODUCTION-2DPAGE P02675; -; . SWISS-2DPAGE P02675; -; . UCD-2DPAGE P02675; -; . PaxDb P02675; -; . PeptideAtlas P02675; -; . PRIDE P02675; -; . Ensembl ENST00000302068; ENSP00000306099; ENSG00000171564; . GeneID 2244; -; . KEGG hsa:2244; -; . CTD 2244; -; . DisGeNET 2244; -; . GeneCards FGB; -; . HGNC HGNC:3662; FGB; . HPA CAB008624; -; . HPA HPA001900; -; . HPA HPA001901; -; . MalaCards FGB; -; . MIM 134830; gene; . MIM 202400; phenotype; . MIM 616004; phenotype; . neXtProt NX_P02675; -; . OpenTargets ENSG00000171564; -; . Orphanet 98880; Familial afibrinogenemia; . Orphanet 98881; Familial dysfibrinogenemia; . Orphanet 248408; Familial hypodysfibrinogenemia; . Orphanet 101041; Familial hypofibrinogenemia; . PharmGKB PA163; -; . eggNOG KOG2579; Eukaryota; . eggNOG ENOG410ZYS4; LUCA; . GeneTree ENSGT00760000118809; -; . HOGENOM HOG000059561; -; . HOVERGEN HBG005707; -; . InParanoid P02675; -; . KO K03904; -; . OMA TIHNGMF; -; . OrthoDB EOG091G03M1; -; . PhylomeDB P02675; -; . TreeFam TF336658; -; . Reactome R-HSA-114608; Platelet degranulation; . Reactome R-HSA-140875; Common Pathway of Fibrin Clot Formation; . Reactome R-HSA-216083; Integrin cell surface interactions; . Reactome R-HSA-354192; Integrin alphaIIb beta3 signaling; . Reactome R-HSA-354194; GRB2:SOS provides linkage to MAPK signaling for Integrins; . Reactome R-HSA-372708; p130Cas linkage to MAPK signaling for integrins; . Reactome R-HSA-5674135; MAP2K and MAPK activation; . Reactome R-HSA-5686938; Regulation of TLR by endogenous ligand; . Reactome R-HSA-6802946; Signaling by moderate kinase activity BRAF mutants; . Reactome R-HSA-6802948; Signaling by high-kinase activity BRAF mutants; . Reactome R-HSA-6802949; Signaling by RAS mutants; . Reactome R-HSA-6802952; Signaling by BRAF and RAF fusions; . Reactome R-HSA-6802955; Paradoxical activation of RAF signaling by kinase inactive BRAF; . ChiTaRS FGB; human; . EvolutionaryTrace P02675; -; . GeneWiki Fibrinogen_beta_chain; -; . GenomeRNAi 2244; -; . PMAP-CutDB P02675; -; . PRO PR:P02675; -; . Proteomes UP000005640; Chromosome 4; . Bgee ENSG00000171564; -; . CleanEx HS_FGB; -; . ExpressionAtlas P02675; baseline and differential; . Genevisible P02675; HS; . GO GO:0072562; C:blood microparticle; IDA:UniProtKB; . GO GO:0005938; C:cell cortex; IEA:Ensembl; . GO GO:0009986; C:cell surface; IDA:BHF-UCL; . GO GO:0009897; C:external side of plasma membrane; IDA:BHF-UCL; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005576; C:extracellular region; NAS:UniProtKB; . GO GO:0005615; C:extracellular space; IDA:UniProtKB; . GO GO:1903561; C:extracellular vesicle; IDA:UniProtKB; . GO GO:0005577; C:fibrinogen complex; IDA:UniProtKB; . GO GO:0005886; C:plasma membrane; TAS:Reactome; . GO GO:0031091; C:platelet alpha granule; IDA:BHF-UCL; . GO GO:0031093; C:platelet alpha granule lumen; TAS:Reactome; . GO GO:0051087; F:chaperone binding; IPI:BHF-UCL; . GO GO:0005198; F:structural molecule activity; IDA:BHF-UCL; . GO GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW; . GO GO:0007596; P:blood coagulation; TAS:Reactome; . GO GO:0072378; P:blood coagulation; fibrin clot formation; IDA:UniProtKB GO GO:0007160; P:cell-matrix adhesion; IDA:BHF-UCL; . GO GO:0043623; P:cellular protein complex assembly; IDA:BHF-UCL; . GO GO:0071347; P:cellular response to interleukin-1; IEA:Ensembl; . GO GO:0044320; P:cellular response to leptin stimulus; IEA:Ensembl; . GO GO:0030198; P:extracellular matrix organization; TAS:Reactome; . GO GO:0042730; P:fibrinolysis; IDA:UniProtKB; . GO GO:0043152; P:induction of bacterial agglutination; IDA:CACAO; . GO GO:0045087; P:innate immune response; IEA:UniProtKB-KW; . GO GO:2000352; P:negative regulation of endothelial cell apoptotic process; IDA:BHF-UCL; . GO GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IDA:BHF-UCL; . GO GO:0031639; P:plasminogen activation; IDA:UniProtKB; . GO GO:0070527; P:platelet aggregation; IDA:BHF-UCL; . GO GO:0002576; P:platelet degranulation; TAS:Reactome; . GO GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IDA:BHF-UCL; . GO GO:0045921; P:positive regulation of exocytosis; IDA:BHF-UCL; . GO GO:0034116; P:positive regulation of heterotypic cell-cell adhesion; IDA:BHF-UCL; . GO GO:0090277; P:positive regulation of peptide hormone secretion; IDA:BHF-UCL; . GO GO:0050714; P:positive regulation of protein secretion; IDA:BHF-UCL; . GO GO:1900026; P:positive regulation of substrate adhesion-dependent cell spreading; NAS:BHF-UCL; . GO GO:0045907; P:positive regulation of vasoconstriction; IDA:BHF-UCL; . GO GO:0051258; P:protein polymerization; IDA:BHF-UCL; . GO GO:0051592; P:response to calcium ion; IDA:BHF-UCL; . GO GO:0002224; P:toll-like receptor signaling pathway; TAS:Reactome; . CDD cd00087; FReD; 1; . Gene3D 3.90.215.10; -; 1; . Gene3D 4.10.530.10; -; 1; . InterPro IPR014716; Fibrinogen_a/b/g_C_1; . InterPro IPR014715; Fibrinogen_a/b/g_C_2; . InterPro IPR002181; Fibrinogen_a/b/g_C_dom; . InterPro IPR012290; Fibrinogen_a/b/g_coil_dom; . InterPro IPR020837; Fibrinogen_CS; . Pfam PF08702; Fib_alpha; 1; . Pfam PF00147; Fibrinogen_C; 1; . SMART SM00186; FBG; 1; . SMART SM01212; Fib_alpha; 1; . SUPFAM SSF56496; SSF56496; 1; . PROSITE PS00514; FIBRINOGEN_C_1; 1; . PROSITE PS51406; FIBRINOGEN_C_2; 1; .

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